« Back to the journal

Every supplement I tried in four years: helped, did nothing, made me worse

Posted by Julie Samson in Histamine on May 12, 2026 · 14 min read


An honest, unsponsored accounting — including the popular ones that wrecked me and the boring ones that quietly changed everything.

I have spent more money on capsules than on my car. Nobody pays me to say any of this, and none of it is medical advice — bodies are wildly individual and mine reacted to things most people tolerate fine. This is a record, not a recommendation.

Genuinely helped

  • DAO enzyme before restaurant meals — did not make me invincible, but cut the flushing and the 3 a.m. wake-up noticeably.
  • Magnesium glycinate at night, started very low. The first real sleep I had in two years.
  • Vitamin C, small doses spread through the day. Larger single doses made me jittery.
  • Molybdenum, at the suggestion of my practitioner, during mold work. Subtle but steady.
  • Cod liver oil in the winter, once my gut could handle fats again.

Did nothing I could detect

  • Three different mushroom blends. Not bad, just no signal.
  • Collagen powder. Everyone loves it. My skin and joints shrugged.
  • A very expensive mitochondrial complex I finished out of stubbornness.

Made me worse

  • A multi-strain probiotic heavy on Lactobacillus casei — three days of flushing and insomnia. Histamine-producing strains are a real thing.
  • Full-dose activated charcoal while still living in the moldy apartment. Crushing fatigue and constipation.
  • Bone broth, which I drank religiously because the internet told me to. High histamine, and it made my sinuses miserable for months before I connected it.
  • Quercetin at the label dose. Half the dose was fine. Dose matters more than I wanted it to.
One new thing at a time, at a quarter of the suggested dose, for five days, written down. I learned more in three months of that than in two years of stacking.

The larger lesson: supplements were never the lever. Getting out of the exposure, sleeping, and eating enough food were the levers. Supplements made the levers easier to pull.


A reminder: I am not a medical professional. This is my experience, written down in case it makes yours less lonely — not a protocol, not advice, and definitely not a substitute for working with someone qualified.


More posts


Slow Healing Letters

One letter, most Sundays — what I'm eating, reading, and quietly changing. Roughly 900 words and a recipe. No protocols, no urgency, nothing you have to buy.