Every supplement I tried in four years: helped, did nothing, made me worse
Posted by Julie Samson in Histamine on May 12, 2026 · 14 min read
An honest, unsponsored accounting — including the popular ones that wrecked me and the boring ones that quietly changed everything.
I have spent more money on capsules than on my car. Nobody pays me to say any of this, and none of it is medical advice — bodies are wildly individual and mine reacted to things most people tolerate fine. This is a record, not a recommendation.
Genuinely helped
- DAO enzyme before restaurant meals — did not make me invincible, but cut the flushing and the 3 a.m. wake-up noticeably.
- Magnesium glycinate at night, started very low. The first real sleep I had in two years.
- Vitamin C, small doses spread through the day. Larger single doses made me jittery.
- Molybdenum, at the suggestion of my practitioner, during mold work. Subtle but steady.
- Cod liver oil in the winter, once my gut could handle fats again.
Did nothing I could detect
- Three different mushroom blends. Not bad, just no signal.
- Collagen powder. Everyone loves it. My skin and joints shrugged.
- A very expensive mitochondrial complex I finished out of stubbornness.
Made me worse
- A multi-strain probiotic heavy on Lactobacillus casei — three days of flushing and insomnia. Histamine-producing strains are a real thing.
- Full-dose activated charcoal while still living in the moldy apartment. Crushing fatigue and constipation.
- Bone broth, which I drank religiously because the internet told me to. High histamine, and it made my sinuses miserable for months before I connected it.
- Quercetin at the label dose. Half the dose was fine. Dose matters more than I wanted it to.
One new thing at a time, at a quarter of the suggested dose, for five days, written down. I learned more in three months of that than in two years of stacking.
The larger lesson: supplements were never the lever. Getting out of the exposure, sleeping, and eating enough food were the levers. Supplements made the levers easier to pull.
A reminder: I am not a medical professional. This is my experience, written down in case it makes yours less lonely — not a protocol, not advice, and definitely not a substitute for working with someone qualified.
More posts
- The apartment that made me sick (and the four years it took to figure it out) (Mold)
- Histamine intolerance is not an allergy — here is how I explain it at dinner (Histamine)
- Revive with Heather review: working with Heather Orricchio (Gut)
Slow Healing Letters
One letter, most Sundays — what I'm eating, reading, and quietly changing. Roughly 900 words and a recipe. No protocols, no urgency, nothing you have to buy.